Class 1A
| School | 2021 Record |
| North Linn | 42-6 |
| Newell-Fonda | 38-4 |
| Lisbon | 37-9 |
| Southeast Warren | 30-3 |
| Collins-Maxwell | 24-3 |
| Wayne | 24-6 |
| Sigourney | 26-9 |
| Remsen St. Mary’s | 21-6 |
| North Butler | 20-7 |
| Martensdale-St. Marys | 19-8 |
| Clarksville | 24-5 |
| Highland | 22-7 |
| Akron-Westfield | 25-3 |
| Central City | 33-10 |
| Griswold | 26-2 |
Class 2A
| School | 2021 Record |
| Central Springs | 31-7 |
| Earlham | 34-10 |
| Wilton | 29-5 |
| Van Meter | 31-8 |
| Interstate 35 | 24-6 |
| North Union | 29-6 |
| Pella Christian | 18-19 |
| Iowa City Regina | 20-13 |
| West Monona | 25-10 |
| Alburnett | 28-13 |
| Hudson | 26-6 |
| Louisa-Muscatine | 20-9 |
| Durant | 16-20 |
| Mount Ayr | 15-13 |
| Jesup | 25-11 |
Class 3A
| School | 2021 Record |
| Davenport Assumption | 40-3 |
| Mount Vernon | 36-5 |
| Williamsburg | 33-11 |
| Anamosa | 32-11 |
| West Burlington/Notre Dame | 30-5 |
| West Liberty | 24-9 |
| Estherville-Lincoln Central | 23-10 |
| Northeast | 26-14 |
| Roland-Story | 24-9 |
| Davis County | 21-8 |
| Sioux Center | 26-7 |
| Sergeant Bluff-Luton | 29-12 |
| West Delaware | 28-10 |
| Eddyville-Blakesburg-Fremont | 27-10 |
| Harlan | 26-12 |
Class 4A
| School | 2021 Record |
| Winterset | 36-8 |
| Western Dubuque | 35-7 |
| Indianola | 34-5 |
| ADM | 26-12 |
| Fairfield | 25-13 |
| Oskaloosa | 22-16 |
| Clear Creek-Amana | 30-10 |
| Bondurant-Farrar | 23-15 |
| Carlisle | 29-11 |
| Creston | 20-12 |
| Bishop Heelan | 31-9 |
| North Polk | 18-16 |
| Dallas Center-Grimes | 22-16 |
| Marion | 26-12 |
| Solon | 26-13 |
Class 5A
| School | 2021 Record |
| Fort Dodge | 38-4 |
| Ankeny Centennial | 33-10 |
| Johnston | 33-9 |
| Muscatine | 35-4 |
| Waukee Northwest | 1st year |
| Bettendorf | 26-16 |
| West Des Moines Valley | 26-15 |
| Linn-Mar | 25-12 |
| Southeast Polk | 21-20 |
| Pleasant Valley | 34-9 |
| Iowa City Liberty | 24-16 |
| Des Moines East | 28-12 |
| Cedar Rapids Prairie | 28-14 |
| Cedar Rapids Jefferson | 26-15 |
| Ames | 20-20 |
